To speed things up a bit, windows caches all the thumbnails it has created in a series of thumbnailcaches. After an extent period of time, these files get huge (before re-installing Vista, my thumbnailcaches had a total size of 900Mb) and big files slow down your system so it's a good things to clean them up.

Where ?
The caches are located in: C:\Users\your_name\AppData\Local\Microsoft\Windows\Explorer\ .

How ?
You'll see 6 files in the folder previously mentioned, select them all and delete them. Explorer will complain that it can't delete the files, but ... it did understand what you wanted to do, because the caches are now 1Mb or 1K each (if not, try deleting them again helps).


Saves you a lot of spaces and time

//edit: I'm not 100% sure, but I think that rebooting completely clears the caches, but again, not sure

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