I can't believe this topic has gone for four pages and noone has mentioned Spyware Doctor! The security combo that I use is Zone Alarm Pro with Anti-Spyware, Spyware Doctor, and AVG Free Anti-Virus. In the last year of surfing the internet, my computer has been 100% up to speed and the only problems I ever have are unrelated to the internet. Believe me when I say this; my computer has visited some pretty bad sites and there has been no impact on my system at all!
A neat feature that Spyware Doctor has, if you have the paid version of course , is the On Gaird protection. As listed on the program, this feature includes:
Cookie Gaurd
Startup Gaurd
Exploit Gaurd
Browser Gaurd
IM Gaurd
Immunizer
Keylogger Gaurd
Network Gaurd
Popup-Blocker
Process Gaurd
Site Blocker
With On Gaurd enabled, there is real-time protection and my system has been protected well

I seriously recommend Spyware Doctor - it has worked for me!
http://www.pctools.com/spyware-doctor/
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